David Kosoff, MD received a Best Poster Award for his poster entitled “Microscale Engineering of the Tumor Microenvironment for Therapeutic Targeting of Tumor-associated Macrophages in Prostate Cancer” at the Association of American Physicians/American Society for Clinical Investigation/American Physician Scientists Association (AAP/ASCI/APSA) Joint Meeting on April 21-23, 2017 in Chicago, Illinois. Only six poster awards were presented at the meeting. 

The work involved use of a novel microfluidic culture platform to culture primary cells (derived directly from patient samples) and cell lines such as epithelial, stromal, and immune cells including macrophages. The microfluidic culture platform allows investigation of the tumor microenvironment and tumor-associated macrophages in prostate cancer. Dr. Kosoff and colleagues have used this approach to evaluate factors such as matrix proteins and general surface properties on prostate cancer, to isolate and extract cell-specific mRNA for expression analysis, to fluorescently label and analyze cellular proteins, and to quantity cell proliferation and viability.  

Dr. Kosoff is enrolled in the Physician-Scientist Training Program (PSTP), in which he combined research training with his residency in internal medicine and fellowship in hematology and medical oncology at the UW-Madison Department of Medicine. He studies under the direction of Joshua Lang, MD, MS, assistant professor, Hematology, Medical Oncology and Palliative Care.  

Resources:

• Kosoff D, Yu J, Lang JM. Microscale Engineering of the Tumor Microenvironment for Therapeutic Targeting of Tumor-associated Macrophages in Prostate Cancer. (Poster PDF)
• Kosoff D, Yu J, Schehr JL, Beebe DJ, Lang JM. 2017. Therapeutic targeting of tumor-associated macrophages through microscale engineering of the prostate cancer microenvironment. J Clin Oncol. 35:184.

Updated September 21, 2021