B-cell Lymphoma Research
Lixin Rui, PhD, is a National Institutes of Health-funded investigator in basic and translational lymphoma research.
His research uses multi-omics approaches and animal models to identify potential molecular targets in cell signaling pathways for development of new therapeutic strategies.
![Portrait of Dr. Lixin Rui](/sites/default/files/styles/standard_component_focal_point_image/public/2024-01/rui_lixin_008-edit-2-20121205-med.jpg?h=9ea07337&itok=uAw1V03n)
Discovering Molecular Targets in B-cell Receptor Pathways
The major research focus of Dr. Rui’s laboratory is the molecular mechanisms of B-cell receptor and JAK-STAT signaling pathways and epigenetic enzymes, including protein arginine methyltransferase 5 (PRMT5) and DNA methyltransferases (DNMTs), in lymphomagenesis.
His research team employs a multidisciplinary approach, using biochemistry, RNA interference, genomic technologies (e.g., ChIP-seq, RNA-seq and single-cell RNA-seq), CRISPR/Cas9 and systems biology methods, to identify mechanisms downstream of the B-cell receptor and JAK-STAT signaling pathways and establish the function of these epigenetic enzymes in B cell lymphoma.
The goal of his research is to discover molecular targets in these pathways for therapeutic, diagnostic and prognostic development of B-cell lymphoma.
Research Team
Postdoctoral Research Assistant
Graduate Research Assistant
Graduate Research Assistant
![Samantha Babel](/sites/default/files/styles/people_component_portraits/public/2023-10/bebel.jpeg?itok=HPmVmTCr)
Samantha Bebel
Undergraduate Student
![Madelyn Chen](/sites/default/files/styles/people_component_portraits/public/2023-10/madelyn-chen.jpeg?itok=Mzy0wIJ-)
Madelyn Chen
Undergraduate Student
![Ruoyu Chen](/sites/default/files/styles/people_component_portraits/public/2023-10/ruoyu-chen.jpeg?itok=r5153tZu)
Ruoyu Chen
Undergraduate Student
![Paul Selberg](/sites/default/files/styles/people_component_portraits/public/2024-01/paul-selberg_1.jpeg?itok=PvFAxCo2)
Paul Selberg
Undergraduate Student
![photo of Dr. Lixin Rui's hand pointing at heatmap charts on a computer screen](/sites/default/files/styles/standard_component_focal_point_image/public/2023-10/rct07876-20220921-med.jpg?h=e7e8c3f0&itok=-YeSrM70)
There are opportunities for motivated individuals in the Rui Lab! We are currently seeking undergraduates, graduate students and postdocs interested in cell signaling and cancer genomic/epigenetic research in B-cell lymphoma.
If you are interested in joining the group, please send your CV and a brief description of your research experience and interests to Dr. Rui.
Active Projects
- EGR1-mediated drug resistance in diffuse large B cell lymphoma
- Role of DNMT3A and DNMT3B in mantle cell lymphoma
- PRMT5 in activation of the PI3K signaling pathway
Funding Support
Dr. Rui’s research is funded by the National Institutes of Health/National Cancer Institute.