Immunology and Genitourinary Tumor Biology
Douglas McNeel, MD, PhD, is a genitourinary medical oncologist with a clinical and laboratory research focus on the immunotherapy of prostate cancer.
Vaccines for Prostate Cancer Treatment
Dr. McNeel’s lab focuses on prostate cancer immunology. Using mouse cancer models and blood/tissue samples from patients with prostate cancer, his team studies how vaccines can be used for the treatment of prostate cancer.
This research has specifically studied the mechanisms of action and resistance to immunization with DNA vaccines, has tested the ability of these vaccines to eliminate prostate cancer cells in laboratory models, and has led to the conduct of several clinical trials with these vaccines.
This work has led to over 100 scientific publications, multiple patents, and a spin-off biotech company.
Agents and approaches to modulate the activation and function of T cells as anti-prostate tumor therapies.
Funding Support
The McNeel lab has been continuously funded for over 20 years by the National Institutes of Health, the Department of Defense Prostate Cancer Research Program, and/or the Prostate Cancer Foundation.
The McNeel Lab has open positions for motivated undergraduate and graduate students, as well as postdoctoral fellows interested in translational research focused on the immunotherapy of prostate cancer.
